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Sexual Abuse: A Journal of Research and Treatment
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Prescription of Medroxyprogesterone Acetate to a Patient with Pedophilia, Resulting in Cushing's Syndrome and Adrenal Insufficiency

Richard B. Krueger

Department of Psychiatry, Columbia University, College of Physicians and Surgeons, rbkl{at}columbia.edu, Sexual Behavior Clinic, New York State Psychiatric Institute, Unit 45, 1051 Riverside Drive, New York, NY, 10032

Wylie Hembree

Departments of Medicine and Obstetrics-Gynecology, Columbia University Medical Center, New York, NY, 10032

Michael Hill

New York State Office of Mental Health, Central New York Psychiatric Center, Marcy, NY, 13403

This article provides a case report of a patient with pedophilia who was treated over a 4-year period with medroxyprogesterone acetate (MPA) at a dose of 300 mg/day and as a consequence developed Cushing's Syndrome and adrenal insufficiency, for which he was treated and from which he recovered. He also reported a hypersexual reaction to his own past cessation of MPA. Gonadotropin-releasing hormone agonists, which have a more benign side-effect profile than MPA, are suggested as an alternative to MPA.

Key Words: medroxyprogesterone acetate • LRHR agonists • leuprolide acetate • antiandrogens • sex offenders • paraphilia • Cushing's syndrome • adrenal insufficiency • hypersexual behavior.

Sexual Abuse: A Journal of Research and Treatment, Vol. 18, No. 2, 227-228 (2006)
DOI: 10.1177/107906320601800208
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